pharma world: medicinal chemistry

Showing posts with label medicinal chemistry. Show all posts

Thursday, March 26, 2009

Medicinal Chemistry of Bioactive Natural Products

Current discoveries and research into bioactive natural products Medicinal Chemistry of Bioactive Natural Products provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world's leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies--developed for natural products--with an emphasis on the structure activity relationship of bioactive natural products. The topics have been carefully chosen on the basis of relevance to current research and to importance as clinicially useful agents.

Rather than attempting to be a comprehensive encyclopedia of bioactive natural products, Medicinal Chemistry of Bioactive Natural Products guides the reader to the key developments in the field. By providing not only practical detail but a historical perspective on the chemistry and biology of the compounds under consideration, the book serves as a handy resource for researchers in their own work developing pharmaceuticals, and as an inspiring introduction for young scientists to the dynamic field of bioactive natural products research.

Enhanced by examples with updated research results, the discussion covers such topics as:
* The chemistry and biology of epothilones
* Vancomycin and other glycopeptide antibiotic derivates
* Antitumor and other related activities of Taxol and its analogs
* The antimalarial properties of the traditional Chinese medicine, Quinghaosu (artemisinin)
* Huperzine A: A natural drug for the treatment of Alzheimer's disease
* The medicinal chemistry of ginkgolides from Ginkgo biloba
* Recent progress in Calophyllum coumarins as potent anti-HIV agents
* Plant-derived anti-HIV agents and analogs
* Chemical synthesis of annonaceous acetogenins and their structurally modified mimics

1 The Chemistry and Biology of Epothilones—Lead Structures for the Discovery of Improved Microtubule Inhibitors (Karl-Heinz Altmann).
2 The Chemistry and Biology of Vancomycin and Other Glycopeptide Antibiotic Derivatives (Roderich D. Su¨ssmuth).
3 Structure Modifications and Their Influences on Antitumor and Other Related Activities of Taxol and Its Analogs (Wei-Shuo Fang, Qi-Cheng Fang, and Xiao-Tian Liang).
4 The Overview of Studies on Huperzine A: A Natural Drug for the Treatment of Alzheimer’s Disease (Da-Yuan Zhu, Chang-Heng Tan, and Yi-Ming Li).
5 Qinghaosu (Artemisinin)—A Fantastic Antimalarial Drug from a Traditional Chinese Medicine (Ying Li, Hao Huang, and Yu-Lin Wu).
6 Progress of Studies on the Natural Cembranoids from the Soft Coral Species of Sarcophyton Genus (Yulin Li, Lizeng Peng, and Tao Zhang).
7 Medicinal Chemistry of Ginkgolides from Ginkgo biloba (Kristian Strømgaard).
8 Recent Progress in Calophyllum Coumarins as Potent Anti-HIV Agents (Lin Wang, Tao Ma, and Gang Liu).
9 Recent Progress and Prospects on Plant-Derived Anti-HIV Agents and Analogs (Donglei Yu and Kuo-Hsiung Lee).
10 Recent Progress on the Chemical Synthesis of Annonaceous Acetogenins and Their Structurally Modified Mimics (Tai-Shan Hu, Yu-Lin Wu, and Zhu-Jun Yao).

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drug synthesis

Contemporary Drug Synthesis by: Jie Jack Li Douglas
Publisher: Wiley-Interscience | ISBN: 0471214809 | 2004-06-25 | Pages: 240 | PDF | 2.7 MB

An integrated and insightful look at successful drug synthesis in today’s drug discovery market
The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug.

Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry’s most respected scientists, this timely volume:

* Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others
* Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis
* Organizes the drugs into fourteen therapeutic areas for clarity and ease of use

Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry
students.

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Friday, March 6, 2009

Introduction to Medicinal Chemistry

This work brigdges the compartmentalized undergraduate organic and biochemistry and biology subjects to the pharmacology and the clinical areas a modern pharmacy practice requires. The changes and constantly increasing responsibilities of today's pharmacist have dictated a restructuring of the pharmacy curriculum, including individual course content. This book reflects and addresses these developments. This is a well-written work that covers most major areas of pharmaceutical research. The text is presented in a logical and concise fashion being divided into chapters based upon therapeutic topic. This makes the work very useful for teaching a course in medicinal chemistry since therapeutic areas can be separately covered without having to make use of the entire book which overall contains a tremendous amount of information. This book is a significant contribution to understanding what medicinal chemistry is and how this science is used to develop new therapeutic agents.

Basic Considerations of Drug Activity.
Mechanisms of Drug Action.
Drug Metabolism and Inactivation.
Anticancer Drugs and Their Mechanism of Action.
Analgetics and Nonsteroidal Antiinflammatory Agents.
Antimicrobial Drugs I. Antimicrobial Drugs II.
Drugs Affecting Cholinergic Mechanisms.
Drugs Affecting Adrenergic Mechanisms.
Drugs and the Cardiovascular Diseases.
Drugs and the Cardiovascular Diseases II.
Psychoactive Drugs--Chemotherapy of the Mind.
Histamine Antagonists and Local Anesthetics.
Steroids.
New Developments and New Problems.
Index.

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Wednesday, November 19, 2008

The Art of Drug Synthesis

The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis.

Edited by prominent scientists working in drug discovery for Pfizer
Meets the needs of a growing community of researchers in pharmaceutical R&D
Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students
An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.

link:-http://rapidshare.com/files/165199484/tart_drg_synth.zip

Burger's Medicinal Chemistry and Drug Discovery, 6 Volume Set

This new sixth edition of Burger's Medicinal Chemistry and Drug Discovery offers several new and unique features. For the first time, an online version of this major reference work will offer updated content from the print edition and easy access. For the first time, all volumes are structured entirely according to content and published simultaneously to provide broad coverage of medicinal chemistry and drug discovery for new or experienced medicinal chemists, biologists, pharmacologists and molecular biologists. This includes a current and global perspective of drug design, and drug development.

With expanded content from 69 chapters to over 100 chapters, this sixth edition of Burger's Medicinal Chemistry and Drug Discovery includes more than 50ew material. An entire section has been dedicated to cancer research. Areas included are those at the foreground of life science including:
* Proteomics
* Genomics
* Bioinformatics
* Combinatorial Chemistry
* High-Throughput Screening
* Blood Substitutes
* Allosteric Effectors as Potential Drugs
* COX Inhibitors
* Statins
* High-Throughput Pharmacology
* and More.

The new sixth edition of Burger's Medicinal Chemistry and Drug Discovery is a Memorial Edition to Professor Alfred Burger who published this major reference work in the first edition as "Medicinal Chemistry" in two volumes in 1951. Dr. Burger's research focused on analgesics, antidepressants and chemotherapeutic agents. He is one of the few academicians to have a drug, designed and synthesized in his laboratories and brought to market. Dr. Burger's contribution to the fields of medicinal chemistry and drug discovery are well renowned and documented. He received the Louis Pasteur Medal of the Pasteur Institute and the American Chemical Society Smissman Award.
link:-http://rapidshare.com/files/151414911/BMCDD6V_.part1.rar
http://rapidshare.com/files/151400676/BMCDD6V_.part2.rar

Saturday, November 8, 2008

medicinal chemistry

mass spectroscopy in drug discovery

Book Description: )

Mass Spectrometry in Drug Discovery summarizes the theory, instrumentation, techniques, and application of mass spectrometry and atmospheric pressure ionization to screening, evaluating, and improving the performance and quality of drug candidates. It provides time- and cost-efficient approaches for the generation and analysis of effective pharmaceuticals, covers advances in combinatorial chemistry, molecular biology, bioanalysis automation, and computing, and demonstrates the use of mass spectrometry in the assessment of disease states, drug targets, and potential drug agents.

http://rapidshare.com/files/1887 ... _Drug_Discovery.rar

Medicinal Chemistry

Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes
Springer | 408 pages | 2008-10-01 | ISBN: 1402068441 | PDF | 6.4 Mb

Fullerenes and nanotubes are two classes of carbon structures or allotropes, which were discovered about 17 years ago. Since that time, many chemical derivatives have been synthesized using fullerenes and nanotubes as building blocks.
Particularly promising was the theory that the chemical properties of fullerenes, and certain derivatives, made them likely candidates for anticancer drugs, inhibitors of viruses such as HIV, or even as anti-bacterials. Their cyctotoxicity can also be controlled by specific circumstances.
In addition, the funtionalization of nanotubes has not only produced relatively simple derivatives, but also complex hybrids with biological macromolecules, which show unique supramolecular architecture and which are promising in many medical applications.

link:-http://depositfiles.com/en/files/7925821

Methods and Principles in Medicinal Chemistry: Microwaves in Organic and Medicinal Chemistry

Wiley-VCH | 2005-11-04 | ISBN: 3527312102 | 422 pages | PDF | 2,4 Mb

The authors of this guide are experts on the use of microwaves for drug synthesis as well as having much experience in teaching courses held under the auspices of the American Chemical Society and the IUPAC. In this handy source of information for any practicing synthetic chemist they focus on common reaction types in medicinal chemistry, including solid-phase and combinatorial methods. They consider the underlying theory, latest developments in microwave applications and include a variety of examples from recent literature, as well as less common applications that are equally relevant for organic and medicinal chemists. An indispensable reference for researchers with an affinity to modern methods.

http://depositfiles.com/files/5392278

Medicinal Chemistry: A Molecular and Biochemical Approach

ISBN: 0195104560
Title: Medicinal Chemistry: A Molecular and Biochemical Approach
Author: Thomas Nogrady, Donald F. Weaver
Publisher: Oxford University Press, USA (2005)
Publication Date: 2005-07-28
Number Of Pages: 672
Average Amazon Rating: 5.0
Book Id 35280
Editorial Description
Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and biochemical principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design.

http://rapidshare.com/files/100180/Medicinal_Chemistry_-_A_Molecular_and_Biochemical_Approach.pdf

Pharmacophores and Pharmacophore Searches (Methods and Principles in Medicinal Chemistry)
Wiley-VCH | ISBN: 3527312501 | 2006-10-27 | PDF | 395 pages | 5.63 Mb | RS

This handbook is the first to address the practical aspects of this novel method. It provides a complete overview of the field and progresses from general considerations to real life scenarios in drug discovery research. Starting with an introductory historical overview, the authors move on to discuss ligand-based approaches, including 3D pharmacophores and 4D QSAR, as well as the concept and application of pseudoreceptors. The next section on structure-based approaches includes pharmcophores from ligand-protein complexes, FLIP and 3D protein-ligand binding interactions. The whole is rounded off with a complete section devoted to applications and examples, including modeling of ADME properties. With its critical evaluation of pharmacophore-based strategies, this book represents a valuable aid for project leaders and decision-makers in the pharmaceutical industry, as well as pharmacologists, and medicinal and chemists.

http://rapidshare.com/files/46800269/Pharmacophores_and_Pharmacophore_Searches.pdf

Thursday, March 26, 2009