Book Description: )
Mass Spectrometry in Drug Discovery summarizes the theory, instrumentation, techniques, and application of mass spectrometry and atmospheric pressure ionization to screening, evaluating, and improving the performance and quality of drug candidates. It provides time- and cost-efficient approaches for the generation and analysis of effective pharmaceuticals, covers advances in combinatorial chemistry, molecular biology, bioanalysis automation, and computing, and demonstrates the use of mass spectrometry in the assessment of disease states, drug targets, and potential drug agents.
http://rapidshare.com/files/1887 ... _Drug_Discovery.rar
Medicinal Chemistry
Medicinal Chemistry
Publisher: New Age International |English | ISBN: 9788122423057 | 960 pages | 2007 | PDF | 31 Mb
http://w17.easy-share.com/1702076127.html
Fullerenes and nanotubes are two classes of carbon structures or allotropes, which were discovered about 17 years ago. Since that time, many chemical derivatives have been synthesized using fullerenes and nanotubes as building blocks.
Particularly promising was the theory that the chemical properties of fullerenes, and certain derivatives, made them likely candidates for anticancer drugs, inhibitors of viruses such as HIV, or even as anti-bacterials. Their cyctotoxicity can also be controlled by specific circumstances.
In addition, the funtionalization of nanotubes has not only produced relatively simple derivatives, but also complex hybrids with biological macromolecules, which show unique supramolecular architecture and which are promising in many medical applications.
link:-http://depositfiles.com/en/files/7925821
Methods and Principles in Medicinal Chemistry: Microwaves in Organic and Medicinal Chemistry
The authors of this guide are experts on the use of microwaves for drug synthesis as well as having much experience in teaching courses held under the auspices of the American Chemical Society and the IUPAC. In this handy source of information for any practicing synthetic chemist they focus on common reaction types in medicinal chemistry, including solid-phase and combinatorial methods. They consider the underlying theory, latest developments in microwave applications and include a variety of examples from recent literature, as well as less common applications that are equally relevant for organic and medicinal chemists. An indispensable reference for researchers with an affinity to modern methods.
Publisher: New Age International |English | ISBN: 9788122423057 | 960 pages | 2007 | PDF | 31 Mb
http://w17.easy-share.com/1702076127.html
Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes
Springer | 408 pages | 2008-10-01 | ISBN: 1402068441 | PDF | 6.4 Mb
Springer | 408 pages | 2008-10-01 | ISBN: 1402068441 | PDF | 6.4 Mb
Fullerenes and nanotubes are two classes of carbon structures or allotropes, which were discovered about 17 years ago. Since that time, many chemical derivatives have been synthesized using fullerenes and nanotubes as building blocks.
Particularly promising was the theory that the chemical properties of fullerenes, and certain derivatives, made them likely candidates for anticancer drugs, inhibitors of viruses such as HIV, or even as anti-bacterials. Their cyctotoxicity can also be controlled by specific circumstances.
In addition, the funtionalization of nanotubes has not only produced relatively simple derivatives, but also complex hybrids with biological macromolecules, which show unique supramolecular architecture and which are promising in many medical applications.
link:-http://depositfiles.com/en/files/7925821
Methods and Principles in Medicinal Chemistry: Microwaves in Organic and Medicinal Chemistry
The authors of this guide are experts on the use of microwaves for drug synthesis as well as having much experience in teaching courses held under the auspices of the American Chemical Society and the IUPAC. In this handy source of information for any practicing synthetic chemist they focus on common reaction types in medicinal chemistry, including solid-phase and combinatorial methods. They consider the underlying theory, latest developments in microwave applications and include a variety of examples from recent literature, as well as less common applications that are equally relevant for organic and medicinal chemists. An indispensable reference for researchers with an affinity to modern methods.
http://depositfiles.com/files/5392278
http://rapidshare.com/files/46800269/Pharmacophores_and_Pharmacophore_Searches.pdf
Medicinal Chemistry: A Molecular and Biochemical Approach
ISBN: 0195104560
Title: Medicinal Chemistry: A Molecular and Biochemical Approach
Author: Thomas Nogrady, Donald F. Weaver
Publisher: Oxford University Press, USA (2005)
Publication Date: 2005-07-28
Number Of Pages: 672
Average Amazon Rating: 5.0
Book Id 35280
Editorial Description
Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and biochemical principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design.
http://rapidshare.com/files/100180/Medicinal_Chemistry_-_A_Molecular_and_Biochemical_Approach.pdf
Pharmacophores and Pharmacophore Searches (Methods and Principles in Medicinal Chemistry)
Wiley-VCH | ISBN: 3527312501 | 2006-10-27 | PDF | 395 pages | 5.63 Mb | RS
Wiley-VCH | ISBN: 3527312501 | 2006-10-27 | PDF | 395 pages | 5.63 Mb | RS
This handbook is the first to address the practical aspects of this novel method. It provides a complete overview of the field and progresses from general considerations to real life scenarios in drug discovery research. Starting with an introductory historical overview, the authors move on to discuss ligand-based approaches, including 3D pharmacophores and 4D QSAR, as well as the concept and application of pseudoreceptors. The next section on structure-based approaches includes pharmcophores from ligand-protein complexes, FLIP and 3D protein-ligand binding interactions. The whole is rounded off with a complete section devoted to applications and examples, including modeling of ADME properties. With its critical evaluation of pharmacophore-based strategies, this book represents a valuable aid for project leaders and decision-makers in the pharmaceutical industry, as well as pharmacologists, and medicinal and chemists.
http://rapidshare.com/files/46800269/Pharmacophores_and_Pharmacophore_Searches.pdf
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