drug delivery

INTRAOCULAR DRUG DELIVERY

This reference studies the most recent advances in the development of ocular drug delivery systems. Covering methods to treat or prevent ocular inflammation, retinal vascular disease, retinal degeneration, and proliferative eye disease, this source covers breakthroughs in the management of endophthalmitis, uveitis, diabetic macular edema, and age-related macular degeneration.
link:-http://rapidshare.com/files/161702326/tintra_dd.zip

DRUG DELIVERY TO LUNG

This book focuses on the aerosol treatment of lung diseases, recent improvements in the understanding of proper dosage, and major innovations in device technology applied to clinical practice. Examines the behavior of inspired spherical particles in the respiratory tract! Featuring over 1300 references, drawings, tables, photographs, and micrographs, Drug Delivery to the Lung · outlines the history of inhaled medications in the treatment of respiratory disease · describes aspects of respiratory structure to inhalation therapy emphasizing developmental changes · compares existing in vitro/in vivo correlations for key aerosol modalities with lung model predictions · discusses particle diameter measurement, particle size statistics, and aerosol test methods · reviews the clinical effects of altering the deposition site of various classes of aerosolized drugs · surveys the development of novel, efficient, and convenient nebulizer systems · details breath-actuated and spacer devices constructed for children · analyzes dry-powder and pressurized metered dose inhalers · considers the transition from CFCs to new environmentally friendly chemical propellants · and more! Giving the clinician an overview of factors essential to understanding drug delivery via nebulization, Drug Delivery to the Lung is a superlative reference for pulmonologists; physiologists; pharmaceutical scientists; immunologists; allergists; analytical, organic, and medicinal chemists and biochemists; chemical, genetic, and process engineers; and medical and graduate school students in these discipline

link:-http://rapidshare.com/files/161701213/tdd_lung.zip

NANOPARTICULATE DRUG DELIVERY SYSTEM

Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. This expertly written guide addresses the scientific methodologies, formulation, processing, applications, recent trends, and emerging technologies in the research of nanoparticulate drug delivery systems (NPDDS). It extensively covers applications of NPDDS, including lipid nanoparticles for dermal applications, nanocarriers for the treatment of restenosis, ocular, central nervous system, and gastrointestinal applications, and use as an adjuvant for vaccine development.
link:-http://rapidshare.com/files/161697760/tnano_dds.zip

SURFACTANTS AND POLYMERS IN DRUG DELIVERY

This reference features the latest findings surrounding the physicochemical aspects of surfactant and polymer systems to facilitate the design and understanding of novel and advanced drug delivery formulations. It covers the basics of surfactant and polymer surface activity and self-assembly, the various types of structures formed by such compounds, and how they may be used in drug delivery. It also discusses solubilization of drugs in micellar systems, liquid crystalline phases formed by PEO-PPO-PEO block copolymers and other copolymers and surfactants, triggered drug-release from liposome formulations, microemulsions formed by ionic and nonionic surfactants, and much more.
link:-http://rapidshare.com/files/160767570/tsurfactant_poly_dd.zip

POLYMERS IN DRUG DELIVERY

In recent years there has been an explosion in the use of polymers to solve various biomedical problems. Polymers play a crucial role in controlling drug release rate, enhancing drug solubility and uptake, and limiting drug degradation and toxicity. Polymers in Drug Delivery is a state-of-the-art documentation and review of all areas in which polymers are used in drug delivery, including hydrogels, soluble polymer drug conjugates, polymeric vesicles and micelles, microspheres, nanoparticles, polymeric in tissue engineering, and more. It is a readily accessible volume suitable for drug delivery scientists and as reading for advanced pharmaceutics students and others new to the field.
link:-http://rapidshare.com/files/160142693/tpoly_dd.zip

OPTHALMIC DRUG DELIVERY

Extensively revised and updated, this second edition compares conventional and innovative drug delivery systems. The book covers significant ophthalmic advances and breakthroughs in gene therapy, ocular microdialysis, vitreous drug disposition modelling, and receptor/transporter targeted drug delivery. It examines procedures in pharmacokinetic/pharmacodynamic modeling for the determination of appropriate dosing regimens, covers new developments in animal modeling, and discusses current regulations governing patenting, commercial product release, and human testing. This in-depth reference lays the groundwork for overcoming constraints on the delivery of ophthalmic drugs.
link:-http://rapidshare.com/files/159219966/tophthalmic_dds2ed.zip

modified-release drugs delivery systems

Describing formulation challenges and their solutions in the design, development, and commercialization of modified-release drugs delivery systems, this book contains eighty papers that review recent developments in design and manufacturing techniques. It includes detailed descriptions of extended release drug products for the oral, nasal, ophthalmic, pulmonary, vaginal, dermal and transdermal pathways. With the exception of the final section addressing regulatory issues, each section covers a particular route for drug delivery and opens with an overview of the anatomical, physiological, and pharmaceutical basics of each route before moving on to cover specific technologies.

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Liposome Technology, Volume I: Liposome Preparation and Related Techniques, Third Edition

Liposome Technology, Volume I: Liposome Preparation and Related Techniques, Third Edition, is a thoroughly updated and expanded new edition of a classic text in the field. Including step-by-step technical details, Volume I illustrates numerous methods for liposome preparation and auxiliary techniques necessary for the stabilization and characterization of liposomes. This source also offers critical discussions of the methodologies of each technology described so that readers can examine the benefits and limitations and compare it to other approaches.

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http://rapidshare.com/files/147377613/tliposome_tech3edv1.zip

Liposome Technology, Volume II: Entrapment of Drugs and Other Materials into Liposomes, Third Edition

Liposome Technology, Volume II: Entrapment of Drugs and Other Materials into Liposomes, Third Edition is a comprehensively updated and expanded new edition of a classic text in the field. Including step-by-step technical details, Volume II describes procedures for the incorporation of drugs and other materials into liposomes for a variety therapeutics, chosen because of their relevance to current trends in liposome applications or because they represent groups of active pharmaceutical ingredients with similar physical and chemical properties. This source also offers critical discussions of the methodologies of each technology described so that readers can examine the benefits and limitations and compare it to other approaches.

link:-http://rapidshare.com/files/147374268/tliposome_tech3edv2.zip

Understanding Drug Release and Absorption Mechanisms: A Physical and Mathematical Approach

Demand for better reliability from drug delivery systems has caused designers and researchers to move away from trial-and-error approaches and toward model-based methods of product development. Developing such models requires cross-disciplinary physical, mathematical, and physiological knowledge. Combining these areas under a single cover, Understanding Drug Release and Absorption Mechanisms builds a firm understanding ofall elements needed to conceive, build, and implement successful models of drug release.

Written by experts with broad industrial and academic experience, this book discusses the underlying physical principles, shows how to build mathematical models based on these principles, and finally compares the resulting models with experimental results. The authors begin by introducing the basics of modeling, physiological details of gastrointestinal and dermal absorption pathways, rheology, mass transport and thermodynamics, dissolution and partitioning, as well as size effects on the dissolution of crystallites. From this baseline, the authors explore applications in drug release from various delivery systems, specifically matrix systems, microemulsions, and permeability through membranes.

Working systematically from theory to working models, Understanding Drug Release and Absorption Mechanisms: A Physical and Mathematical Approach demonstrates the steps involved in designing, building, and implementing realistic and reliable models of drug release without unrealistically simplifying the theoretical parameters.

link:-http://rapidshare.com/files/139166603/tdrug_relea_absor.zip

Mechanisms of Transdermal Drug Delivery

Provides an up-to-date and critical examination of biophysical techniques used in the analysis of molecular mechanisms underlying transdermal drug delivery as well as a physical and chemical evaluation of the stratum corneum necessary for the enhancement of percutaneous drug transport. Reflects the hands-on experience of established and novel researchers in the field.
link:-http://rapidshare.com/files/138655726/tmech_transd_dd.zip

Cellular Drug Delivery: Principles and Practice

An authoritative and up-to-date survey of the fundamental principles, and practice of drug delivery at the cellular level. On the principles side, the authors discuss the broad spectrum of cellular delivery, ranging from coverage of cell-mediated immunity, gene delivery, and protein targeting, to cellular drug transport, cellular drug permeability, and a variety of carrier system related to targeted drug delivery. On the practice side, the authors focus on technological developments in cellular drug delivery, including novel formulations for the delivery of DNA and antisense oligonucleotides ,as well as drug targeting with immunoglobulin formulations and antibody-mediated approaches.

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Microencapsulation

Presenting practical approaches to complex formulation problems, this outstanding reference provides a thorough overview of particulate delivery systems-emphasizing specific preparation, characterization, and evaluation methods, as well as potential applications in areas such as pharmacy, medicine, cosmetology, and agriculture.

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http://rapidshare.com/files/115263505/Microencapsultion.zip

Water-Insoluble Drug Formulation, Second Edition

Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone, or completely derail, important new drug development. Even much-needed reformulation of currently marketed products can be significantly affected by these challenges.

Water Insolubility is the Primary Culprit in over 40% of New Drug Development Failures

The most comprehensive resource on the topic, this second edition of Water Insoluble Drug Formulation brings together a distinguished team of experts to provide the scientific background and step-by-step guidance needed to deal with solubility issues in drug development. Twenty-three chapters systematically describe solubility properties and their impact on formulation, from theory to industrial practice. With detailed discussion on how these properties contribute to solubilization and dissolution, the text also features six brand new chapters on water-insoluble drugs, exploring regulatory aspects, pharmacokinetic behavior, early phase formulation strategies, lipid based systems for oral delivery, modified release of insoluble drugs, and scalable manufacturing aspects. The book includes more than 15 water-insoluble drug delivery systems or technologies, illustrated with case studies featuring oral and parenteral applications. Highlighting the most current information and data available, this seminal volume reflects the significant progress that has been made in nearly all aspects of this field.

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http://rapidshare.com/files/104001867/Wtr_inso_drg_formu_2Ed.zip

Drug Delivery Systems

The field of drug development and therapeutics can be overwhelmingly encyclopedic and vast. In Drug Delivery Systems, Dr. Kewal Jain and a team of experts select the most important, cutting-edge technologies used in drug delivery systems taking into account significant drugs, new technologies such as nanoparticles, and therapeutic applications. The chapters present step-by-step laboratory protocols following the highly successful Methods in Molecular Biology series format, offering readily reproducible results vital for pharmaceutical physicians and scientists.

Concise and systematic, Drug Delivery Systems is a powerful reference tool for the hundreds of companies developing drug delivery technologies all around the world.

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http://rapidshare.com/files/94727479/Dd_sys.zip

Drug Delivery to the Oral Cavity

With contributions from recognized authorities in industry, academia, and government, this reference presents the state-of-the-art in the testing, formulation, and clinical evaluation of intraoral drug delivery products-summarizing intraoral dosage forms in various stages of research, as well as products currently on the market.

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http://rapidshare.com/files/86404580/Drug_Delivery_Oral_Cav.zip

patents

Research and Development of Vaccines and Pharmaceuticals from Biotechnology: A Guide to Effective Project Management, Patenting and Product Registrati

This book has been written for researchers in academic laboratories and industry, who are currently experiencing exciting scientific changes in the traditionally empiric life sciences, which coincide with a growing economic awareness in these areas. The biomedicinal sciences are particularly affected by an increasing dicotomy between highly innovative research and -due to regulatory limitations - very conservative development of pharmaceutical products. Scientists who are engaged in applied research or development, spanning the widening gap between fundamental research and its application, have to cope with increasing scientific and regulatory demands. Rising concerns about the cost of research and development, time performance and competitiveness cause additional distress.

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http://rapidshare.com/files/132988566/Rnd_vaccines_pharma.zip

Competition Law and Patents: A Follow-on Innovation Perspective in the Biopharmaceutical Industry

In June 2005 the European Commission announced that it had fined AstraZeneca €60 million for misusing the patent system to delay entry of competitors thereby abusing its dominant position in contravention of Art. 82 EC. In October 2005 a complaint by six phone manufacturers was reported against Qualcomm, a chip manufacturer that owns patents over technology used in 3G handsets, alleging that Qualcomm refused to license essential patents on fair terms, and charged excessive royalties for its essential patents thereby acting anti-competitively. In December 2005 the Commission published a Discussion Paper on the Application of Art. 82 to Exclusionary Abuses. In February 2007 the Commission opened an investigation into Boehringer’s best selling drug last year, Spiriva, in relation to possible misuses of the patent system to exclude competition from the market.

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http://rapidshare.com/files/131260102/Compet_law_paten.zip

Patent Failure: How Judges, Bureaucrats, and Lawyers Put Innovators at Risk

n the last several years, business leaders, policymakers, and inventors have complained to the media and to Congress that today's patent system stifles innovation instead of fostering it. But like the infamous patent on the peanut butter and jelly sandwich, much of the cited evidence about the patent system is pure anecdote--making realistic policy formation difficult. Is the patent system fundamentally broken, or can it be fixed with a few modest reforms? Moving beyond rhetoric, Patent Failure provides the first authoritative and comprehensive look at the economic performance of patents in forty years. James Bessen and Michael Meurer ask whether patents work well as property rights, and, if not, what institutional and legal reforms are necessary to make the patent system more effective.

Patent Failure presents a wide range of empirical evidence from history, law, and economics. The book's findings are stark and conclusive. While patents do provide incentives to invest in research, development, and commercialization, for most businesses today, patents fail to provide predictable property rights. Instead, they produce costly disputes and excessive litigation that outweigh positive incentives. Only in some sectors, such as the pharmaceutical industry, do patents act as advertised, with their benefits outweighing the related costs.

By showing how the patent system has fallen short in providing predictable legal boundaries, Patent Failure serves as a call for change in institutions and laws. There are no simple solutions, but Bessen and Meurer's reform proposals need to be heard. The health and competitiveness of the nation's economy depend on it.

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http://rapidshare.com/files/127775918/Patent_failure.zip

International Pharmaceutical Registration

The increasing globalization of pharmaceutical markets and continuing consolidation within the pharmaceutical industry have highlighted the challenges of rapidly evolving regulatory requirements and created a much greater appreciation of the need for regulatory awareness throughout the industry. This book provides a practical overview and guide to the complexities of international pharmaceutical registration. With individual country chapters written by experts within that country drawn from regulatory authorities, international pharmaceutical companies, and regulatory consultants, the book comprehensively covers regulations across the globe.

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http://rapidshare.com/files/65008233/Inter_Pharma_Rreg.zip

Practical Guide to the Care of the Medical PatientIf you need a practical, portable resource to get you through your internal medicine clerkship or residency, this book is the answer! It zeroes right in on the differential diagnoses, clinical findings, lab values, and treatment guidelines you need to diagnose and manage more than 225 disorders, signs, and symptoms...and makes them easy to access quickly! This 7th Edition covers 53 new differential diagnoses and 37 new topics...includes more color dermatology images...and features a more compact format for increased portability and ease of use.

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http://rapidshare.com/files/62225986/Care_of_the_Medical_Patient.zip

The Handbook of Patient Safety Compliance: A Practical Guide for Health Care Organizations

Written for virtually every professional and leader in the health care field, as well as students who are preparing for careers in health services delivery, this book presents a framework for developing a patient safety program, shows how best to examine events that do occur, and reveals how to ensure that appropriate corrective and preventative actions are reviewed for effectiveness. The book covers a comprehensive selection of topics including

• The link between patient safety and legal and regulatory compliance
• The role of accreditation and standard-setting organizations in patient safety
• Failure modes and effect analysis
• Voluntary and regulatory oversight of medical error
• Evidence-based outcomes and standards of care
• Creation and preservation of reports, data, and device evidence in medical error situations
• Claims management when dealing with patient safety events
• Full disclosure
• Patient safety in human research
• Managing confidentiality in the face of litigation
• Managing patient safety compliance through accountability-based credentialing for health care professionals
• Planning for the future

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http://rapidshare.com/files/62199078/Patient_Safety_Compliance.zip

Filing Patents Online: A Professional Guide

Securing a patent through the traditional paper process is slow and expensive. Market demands and the worldwide migration to online patent application systems require attorneys and inventors alike to become familiar with Wweb-based filing. Pursuing patents via the Internet is quicker and more affordable, and makes good business sense. Unfortunately, existing online patent software is cumbersome and difficult to master, forcing many inventors and attorneys to rely on outdated, expensive methods. Filing Patents Online: A Professional Guide provides patent attorneys, inventors, and businesses with a step-by-step guide for filing and pursuing patents electronically. This comprehensive analysis of online patent systems from around the world recommends the proper choices for filers, saving time and money and increasing the odds of success. By following the hands-on examples of real filings contained in this book and its accompanying media kit, you can harness the power of the Internet to research, plan, and write winning claims. Filing Patents Online can result in thousands of dollars in savings and a secured patent that will keep a company ahead of the competition.

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http://rapidshare.com/files/54853938/Filing_Patents_Online.zip

The Art of Drug Synthesis

The Art of Drug Synthesis

The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis.

• Edited by prominent scientists working in drug discovery for Pfizer
• Meets the needs of a growing community of researchers in pharmaceutical R&D
• Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students
• An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.

link:-http://rapidshare.com/files/165199484/tart_drg_synth.zip

Burger's Medicinal Chemistry and Drug Discovery, 6 Volume Set

This new sixth edition of Burger's Medicinal Chemistry and Drug Discovery offers several new and unique features. For the first time, an online version of this major reference work will offer updated content from the print edition and easy access. For the first time, all volumes are structured entirely according to content and published simultaneously to provide broad coverage of medicinal chemistry and drug discovery for new or experienced medicinal chemists, biologists, pharmacologists and molecular biologists. This includes a current and global perspective of drug design, and drug development.

With expanded content from 69 chapters to over 100 chapters, this sixth edition of Burger's Medicinal Chemistry and Drug Discovery includes more than 50ew material. An entire section has been dedicated to cancer research. Areas included are those at the foreground of life science including:
* Proteomics
* Genomics
* Bioinformatics
* Combinatorial Chemistry
* High-Throughput Screening
* Blood Substitutes
* Allosteric Effectors as Potential Drugs
* COX Inhibitors
* Statins
* High-Throughput Pharmacology
* and More.

The new sixth edition of Burger's Medicinal Chemistry and Drug Discovery is a Memorial Edition to Professor Alfred Burger who published this major reference work in the first edition as "Medicinal Chemistry" in two volumes in 1951. Dr. Burger's research focused on analgesics, antidepressants and chemotherapeutic agents. He is one of the few academicians to have a drug, designed and synthesized in his laboratories and brought to market. Dr. Burger's contribution to the fields of medicinal chemistry and drug discovery are well renowned and documented. He received the Louis Pasteur Medal of the Pasteur Institute and the American Chemical Society Smissman Award.
link:-http://rapidshare.com/files/151414911/BMCDD6V_.part1.rar
http://rapidshare.com/files/151400676/BMCDD6V_.part2.rar