G Protein-coupled Receptors

G Protein-coupled Receptors: Molecular Pharmacology By Georges Vauquelin, Bengt von Mentzer

Publisher: Wiley | 28-01-2008 | ISBN: 047051647X | 264 pages | 73.9 Mb

G protein-coupled receptors (GPCRs) are membrane proteins that transduce a vast array of extracellular signals into intracellular reactions ranging from cell-cell communication processes to physiological responses. They play an important role in a variety of diseases from cancer and diabetes, to neurodegenerative, inflammatory and respiratory disorders. GPCRs are therefore of utmost interest in drug development: over half of all prescription drugs currently on the market act by targeting these receptors directly or indirectly.

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